David Boaz (born 1953), Executive Vice President of the Cato Institute, Born in Mayfield
Ben M. Bogard (1868–1941), Clergyman, founder of American Baptist Association; pastor of Antioch Missionary Baptist Church of Little Rock, Arkansas, pastor under
LaVerne Butler (1926–2010), Clergyman and college president, Born in Henderson County; pastor of 9th & O Baptist Church in Louisville, president of Mid-Continent University in Mayfield, also resided in Lexington
Brian Cashman (born 1967), Senior VP and general manager of New York Yankees, Raised in Lexington
Edgar Cayce (1877–1945), Mystic, Born in Beverly, seven miles (11 km) south of Hopkinsville
Thomas D. Clark (1903–2005), Historian credited with preserving much of Kentucky's history, Lived in Lexington, taught at University of Kentucky for more than seven decades
Chris Clarke (born 1957), Southern Baptist missionary to the equestrian community, Operates Happy Trails Ministry in Burna
David and Mary Conley, The Amazing Race contestants known as "Team Kentucky", Live in Stone
Tara Conner (born 1985), 2006 Miss USA, Raised from early childhood in Russell Springs
Mordecai Ham (1877–1961), Tent revivalist who preached the sermon, converting Billy Graham to Christianity, Born in Allen County
Heather French Henry (born 1974), 2000 Miss America, Born in Augusta, raised in Maysville
Duncan Hines (1880–1959), Food critic, Born in Bowling Green
Willie K. Hocker (1862–1944), Designer of the Arkansas state flag, Born in Madison County
Robert S. James (1818–1850), Revivalist Pastor; father of Jesse James and Frank James; co-founder of William Jewell College, Born in Logan County
Casey Jones (1864–1900), Railroad engineer of song; killed trying to stop a train collision; subject of a television series based loosely on his career, Born in Cayce
Brandi Mudd (born 1989), Elementary school teacher and contestant from MasterChef season 7, Born in Irvington
Venus Ramey (1924–2017), 1944 Miss America, Born in Ashland, raised in Paintsville
Gene Robinson (born 1947), First openly gay noncelibate Episcopal bishop, Born in Lexington
Col. Harland Sanders (1890–1980), Founder of KFC, Lived in Corbin
"Papa" John Schnatter (born 1962), Founder of Papa John's Pizza, Lives in Anchorage